Naproxen belongs to famous NSAID group of drugs that are meant to deal with RA and some other forms of arthritis and several more conditions. As for vicodin it is a pain reliever, meant to deal with moderate to severe pain. Can you mix oxycodone with naproxen?. Can you mix Vicodin with oxycodone? You should not exceed more than 650-1,000 mg of acetaminophen within 4 hours. Previous FDA guideline was that you may. Common Questions and Answers about Percocet with naproxen percocet hi there, ive been into two accidents and i took physiotherapy, didnt work much, my doctor stopped prescribing me percocet and gave me naproxen, which does not help! Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Sauer on mixing naproxen and ibuprofen: Naprosyn (naproxen) and Ibuprofen are both NSAIDS, so you can not take both, but you may take naprosyn (naproxen) as instructed to instead of the Ibuprofen.BUT note, it is important for continuity of care and good pt/Dr relations to inform your treating Doctor of the. Naproxen and acetaminophen both treat mild to moderate pain, but they work differently. Learn if you can take them together and how to use them safely. Newsletter. Is It Safe to Mix Naproxen and. can i take mucinex with naproxen and vicodin. Can patients take Hydrocodone and Naproxen or Aleve together From a pharmacology standpoint, there is no harm if Naproxen or Aleve is taken together with Hydrocodone. So if hydrocodone isn’t controlling the pain well, patients can use Naproxen or Aleve and Hydrocodone but only with physician instructions. Common Questions and Answers about Can i take hydrocodone with naproxen. vicodin. I get migraines too and I also have a whole host of things wrong with my back. I don't take pain medication. Unless I am in a car accident or the pain is so bad that I would rather DIE than feel it for one more second, I will NOT take them. Believe me, I know how bad migraines can get. I can't focus, or watch TV. I know that it's not good to mix these drugs and I'm afraid that 500mg of naproxen is too much for hydrocodone. I want to know something more about these medicaments. Thanks! I want to know something more about these medicaments. I've been on 7.5 Vicodin for years. It works very well with ibuprophen, especially in the prescription strength. I get 800mg. I have been prescribed all 3 of those to take together, for me it was safe and effective, although, I didn't think soma was very strong.